Custom Peptides
Cayman Chemical 14-DeoxyndrographolIde 10mg
A diterpene lactone with diverse biological properties; inhibits the growth of HL-60 cells (GI50 = 25.46 µM); cytotoxic to T47D cells (EC50 = 2.8 UG/ml); increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells at 10 and 25 µM; reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice at 100 mg/kg; reduces ethanol-induced hepatotoxicity in rats at 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period; reduces protein carbonyl and TBARS levels and increases GSH levels in isolated rat hepatocytes in the same model
Cayman Chemical ARUK3001185 10mg
An inhibitor of NOTUM (IC50 = 6.7 nM); selective for NOTUM over a panel of 39 serine hydrolases and 485 kinases, including CK1 and GSK3, at 10 µM and a panel of 47 receptors, ion channels, transporters, and enzymes at 30 µM, but does inhibit 5-HT3A, α4β2 subunit-containing nAChRs, and MAO-A (IC50s = 4.5, 10, and 28 µM, respectively); prevents NOTUM-induced decreases in Wnt3a signaling in a cell-based reporter assay (EC50 = 110 nM)
Cayman Chemical PyrIdostIgmIn-d3bromIde 10mg
An internal standard for the quantification of pyridostigmine by GC- or LC-MS
Cayman Chemical Desmethyl CarvedIlol 10mg
An active metabolite of carvedilol; inhibits store-overload-induced calcium release in HEK293 cells expressing RyR2R4496C (IC50 = 7.62 µM); reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by isoproterenol in conscious rabbits (ED50s = 32 and 5 UG/kg)
Cayman Chemical IsodeoxycholIc AcId 10mg
A bile acid and an FXR agonist; induces FXR-mediated gene expression in a reporter assay using COS-7 cells at 30 µM; activates KCa1.1/BK in isolated rabbit superior mesenteric arteries
Cayman Chemical L-368 899hydrochlorIde 10mg
A non-peptide oxytocin receptor antagonist (IC50s = 8.9 and 26 nM in radioligand binding assays using isolated human and rat uterus, respectively); selective for oxytocin receptors over vasopressin V1a and V2 receptors (IC50s = 370 and 570 nM, respectively); reduces oxytocin-induced contraction of isolated rat uterus (pA2 = 8.9) and in situ rat uterus (ED50 = 0.35 mg/kg, i.v.)
Cayman Chemical Gap 27trIfluoROCTAte salt 10mg
A connexin-mimetic peptide; reduces survival of isolated rat osteoclasts at 500 µM; decreases bone resorption in rat bone slice and osteoclast co-cultures; accelerates wound closure and stratification of the corneal epithelium in isolated human corneas; reduces cardiac remodeling and the incidence of cardiac arrhythmias in a rat model of AV-shunt surgery-induced high-output heart failure
Cayman Chemical GoralatIdeacetate 10mg
A tetrapeptide regulator of hematopoiesis; decreases the proportion of mouse HPP-CFCs in S phase when cultured using regenerating femoral marrow conditioned medium at 1 ng/ml; reduces 5-FU-induced decreases in the number of HPP-CFCs, BFU-E cells, and CFU-GMs in mice at 4 UG/kg twice per day; reduces doxorubicin-induced mortality in mice
Cayman Chemical Metapramn 10mg
An antidepressant; decreases action potential amplitude and maximal signal velocity and increases conduction time in isolated dog Purkinje fibers at 10 µM; reduces ethanol consumption in ethanol-preferring rats at 10 mg/kg; inhibits reperfusion-induced increases in ventricular arrhythmias in a rat model of myocardial ischemia-reperfusion injury induced by ligation of the LAD artery at 175 µM; increases the latency to tail withdrawal in the tail-flick test and inhibits phenylbenzoquinone-induced writhing in mice at 10 mg/kg
Cayman Chemical 3-DeoxyurIdIn 10mg
A dehydroxylated derivative of uridine; inhibits uridine phosphorylase isolated from T. gondii (apparent Ki = 2.459 mM); decreases the proliferation of CCRF CEM, L1210, P388, and S180 cancer cells (EC50s = 25, 5, 2.5, and 15 µM, respectively); reduces the infection rate and number of T. cruzi amastigotes in HeLa cells at 1 µM; induces sodium currents in X. laevis oocytes expressing human CNT 1 or CNT 3 at 500 µM
Cayman Chemical Cambendazol 10mg
An antihelmintic agent; eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle at a dose of 50 mg/kg/day; inhibits polymerization of microtubules isolated from bovine brain (IC50 = 64.2 µM)
Cayman Chemical Lnoprdn 10mg
An enhancer of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate by blocking M-type K+ current (IC50 = 2.4 µM); also acts as an agonist of TRPV1 (EC50 = 115 µM in HEK293 cells voltage clamped at -60 mV)
Cayman Chemical ClopIdogrel Carylc ACD 10mg
An inactive metabolite of (±)-clopidogrel and (S)-(+)-clopidogrel
Cayman Chemical Annaosanchun 10mg
A synthetic sterol and neuroprotective agent; increases the viability of, and the levels of ATP and the mitochondrial membrane potential in, hypoxia-exposed and reoxygenated primary rat cortical neurons at 0.1, 0.3, and 1 µM; prevents glutamate-induced increases in intracellular acidification, lactate levels, and glycolysis rate, as well as inhibits glutamate-induced apoptosis, in primary rat cerebral granule neurons at 10 µM; reduces neurological and neuromuscular deficits and infarct volume in a rat model of MCAO-induced ischemia-reperfusion injury at 0.5, 2, or 10 mg/kg